Synergistic Photodynamic/Antibiotic Therapy with Photosensitive MOF-Based Nanoparticles to Eradicate Bacterial Biofilms

Bacterial biofilms pose a serious threat to human health, as they prevent the penetration of antimicrobial agents. Developing nanocarriers that can simultaneously permeate and deliver antibacterial agents is an attractive means treating bacterial biofilm infections. Herein, photosensitive metal–organic framework (MOF) nanoparticles were developed promote antibiotics into biofilms, thereby achieving goal eradicating through synergistic photodynamic antibiotic therapy. First, ligand containing benzoselenadiazole was synthesized incorporated MOF skeletons construct benzoselenadiazole-doped MOFs (Se-MOFs). The growth Se-MOFs could be regulated obtain (Se-NPs) in presence benzoic acid. singlet oxygen (1O2) generation efficiencies Se-NPs evaluated. results show exhibited higher 1O2 efficacy than Se-MOF under visible-light irradiation because small size conducive diffusion 1O2. Afterward, drug, polymyxin B (PMB), conjugated onto surface via amidation yield PMB-modified (PMB-Se-NPs). PMB-Se-NPs exhibit effect by specifically targeting lipopolysaccharides present outer membranes Gram-negative bacteria surface-modified PMB. Benefiting from therapeutic effects therapy, efficiently eradicate at relatively low doses light intensities, providing promising nanocomposite for combating